GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9296095 | 1 | rs5745568 | chr6:33548394 | C6orf227 | chr6:33553883-33561115:- | -0.23 | -3.98 | 8.1E-5 | Platelet count |
| THCA | cis | rs9296095 | 1 | rs5745582 | chr6:33546498 | C6orf227 | chr6:33553883-33561115:- | -0.21 | -3.75 | 0.000197 | Platelet count |
| THCA | cis | rs17122021 | 1 | rs57461652 | chr11:118146197 | AMICA1 | chr11:118064442-118095809:- | 0.08 | 4.01 | 7.05E-5 | Pain |
| THCA | cis | rs17122021 | 1 | rs57461652 | chr11:118146197 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.86 | 2.62E-14 | Pain |
| THCA | cis | rs17122021 | 1 | rs57461652 | chr11:118146197 | TREH | chr11:118528942-118550381:- | -0.17 | -3.39 | 0.000746 | Pain |
| THCA | cis | rs9815354 | 1 | rs57479675 | chr3:41798038 | ULK4 | chr3:41288091-42003660:- | 1.09 | 19.98 | 5.2E-65 | Diastolic blood pressure |
| THCA | cis | rs7118648 | 1 | rs57493332 | chr11:96115556 | CCDC82 | chr11:96085930-96123083:- | -0.24 | -3.59 | 0.000363 | Parkinson's disease |
| THCA | cis | rs2076028 | 1 | rs5750621 | chr22:38956166 | JOSD1 | chr22:39081549-39096459:- | -0.16 | -4.11 | 4.7E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750621 | chr22:38956166 | TOMM22 | chr22:39077954-39080763:+ | -0.2 | -4.35 | 1.67E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750622 | chr22:38956464 | JOSD1 | chr22:39081549-39096459:- | -0.15 | -4.04 | 6.14E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750622 | chr22:38956464 | TOMM22 | chr22:39077954-39080763:+ | -0.19 | -4.23 | 2.76E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750626 | chr22:38977890 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -3.66 | 0.000276 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750626 | chr22:38977890 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.5 | 0.000506 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750626 | chr22:38977890 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.68 | 0.00026 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750627 | chr22:38982321 | LOC646851 | chr22:38974125-39052634:- | 0.14 | 3.74 | 0.000209 | Resting heart rate |